Role of SNP rs510432 of autophagy related gene ATG5 in Asthma

Abstract

Asthma is an inflammatory disease that affects the respiratory system which causes episodes of breathlessness, wheezing, cough and chest pain [1, 7]. It is a very common disease affecting millions of people worldwide every year. According to World Health Organization, around 250-300 million people are globally affected by asthma, with around 15-20 million people in India including 10-15% children between the age of 5-11 years [8]. The exact cause for asthma is currently not known although it is thought to be induced by various environmental as well as genetic factors [9, 10]. These all factors collectively are responsible for disease prevalence in an individual [11]. We conducted this study on the north Indian population to find out the significance of one such genetic factor responsible for asthma susceptibility.