Investigation of the Role of quercetin and Rutin on Diabetes Associated Behavioral Dysfunction in Swiss Albino Mice

Abstract

The study was designed to investigate the effect of antidiabetic drugs and antioxidants on STZ induced diabetic mice on the basis of anxiety testing. Animals were divided into groups (Control, Control+Rosiglitazone, Control+Quercetin, Control+Rutin ,induced with Diabetes (STZ induced, STZ+Rosiglitazone, STZ+Quercetin, STZ+Rutin)) and were orally administered with the drug i.e Rosiglitazone(both control, STZ induced) , antioxidant i.e Quercetin, Rutin for 21days. Anxiety and Stress behaviour was assessed from day 22-27 in which the anxiety and stress was checked through Anxiety testing method Elevated Plus Maze (EPM). Results revealed that animals induced with STZ were having high anxiety and stress compared to those of control, Diabetic animals which were subjected to Rosiglitazone showed freezing, slow locomotion effect and those subjected to quercetin showed reduced anxiety, attenuated depression, reduced freezing and normalized locomotion activity. Results revealed that time taken by the control animals was equal to that taken by the STZ+ Quercetin.