Annotation of Biological Systems using Top down approach of Systems Biology

Abstract

With the evolution of human race so did evolve the diseases we fell hostile to. More complex systems as of ours’, translates to more complicated and intricately regulated diseases that attack it. The complexity of our system is not defined by the simple elements that interact in different ways to give a complex system but by the interaction of simple elements (such as ions) and complex elements (such as genes, proteins, regulatory factors etc.) at varied conditions, at varied concentrations and that too in different systems differently. Also a biological system is comprised of large numbers of functionally diverse and frequently multifunctional sets of elements (internally or externally of the system) which interact selectively and nonlinearly to produce coherent and complex behaviors. In spite of such complexities and variations across systems certain patterns are well conserved and regulated.